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L-Myc
a proto-oncogenic transcription factor. Targets include CCL6 chemokine gene. Plays a role in cell proliferation, apoptosis and in the development of human tumors. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Oncoprotein; Transcription factor |
| Chromosomal Location of human Ortholog: 1p34.2 |
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Cellular Component:
chromatin; chromosome; nucleoplasm
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Molecular Function:
DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Biological Process:
regulation of inner ear auditory receptor cell differentiation; regulation of transcription by RNA polymerase II
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Reference #:
P12524
(UniProtKB)
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Alt. Names/Synonyms: BHLHE38; Class E basic helix-loop-helix protein 38; L-Myc; l-myc protein; l-myc-1 proto-oncogene; LMYC; myc-related gene from lung cancer; MYCL; MYCL proto-oncogene, bHLH transcription factor; MYCL1; oncogene lmyc; Protein L-Myc; Protein L-Myc-1; v-myc avian myelocytomatosis viral oncogene homolog 1, lung carcinoma derived; v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog; V-myc myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived; v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)
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Gene Symbols: MYCL
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Molecular weight:
40,327 Da
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Basal Isoelectric point:
5.47
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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