NFATC2IP In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component:  cytoplasm; nucleus
Biological Process:  cytokine production; positive regulation of transcription by RNA polymerase II
Reference #:  Q8NCF5 (UniProtKB)
Alt. Names/Synonyms: 45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; ESC2; FLJ14639; MGC126790; MGC138387; NF2IP; NFATC2-interacting protein; NFATC2IP; NIP45; nuclear factor of activated T cells 2 interacting protein; Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein; RAD60
Gene Symbols: NFATC2IP
Molecular weight: 45,817 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Select Structure to View Below

NFATC2IP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene