VEGFR2 Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. Detected in cornea (at protein level). Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; VEGFR family
Chromosomal Location of Human Ortholog: 5 C3.3|5 40.23 cM
Cellular Component:  cell junction; cell periphery; cell surface; cytoplasm; cytoplasmic vesicle; early endosome; endoplasmic reticulum; endosome; external side of plasma membrane; extracellular region; Golgi apparatus; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; neuron projection; neuronal cell body; nucleus; plasma membrane; receptor complex; sorting endosome
Molecular Function:  ATP binding; cadherin binding; growth factor binding; identical protein binding; integrin binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor binding; vascular endothelial growth factor-activated receptor activity
Biological Process:  angiogenesis; blood vessel endothelial cell differentiation; branching morphogenesis of an epithelial tube; calcium ion homeostasis; calcium-mediated signaling using intracellular calcium source; cell differentiation; cell fate commitment; cell maturation; cell migration; cell migration involved in sprouting angiogenesis; cellular response to hydrogen sulfide; cellular response to vascular endothelial growth factor stimulus; embryonic hemopoiesis; endocardium development; endochondral bone growth; endothelial cell differentiation; endothelium development; ERK1 and ERK2 cascade; hemopoiesis; lung alveolus development; lung development; lymph vessel development; male gonad development; multicellular organism development; negative regulation of apoptotic process; negative regulation of endothelial cell apoptotic process; negative regulation of gene expression; negative regulation of neuron apoptotic process; neuron projection morphogenesis; ovarian follicle development; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of angiogenesis; positive regulation of blood vessel diameter; positive regulation of blood vessel endothelial cell migration; positive regulation of BMP signaling pathway; positive regulation of calcium-mediated signaling; positive regulation of cell migration; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell proliferation; positive regulation of cytosolic calcium ion concentration; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of focal adhesion assembly; positive regulation of long-term neuronal synaptic plasticity; positive regulation of macroautophagy; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of mitochondrial depolarization; positive regulation of mitochondrial fission; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of positive chemotaxis; positive regulation of protein phosphorylation; positive regulation of TOR signaling; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of vasculogenesis; post-embryonic camera-type eye morphogenesis; protein autophosphorylation; protein kinase B signaling; protein phosphorylation; regulation of bone development; regulation of cell shape; regulation of endothelial cell differentiation; regulation of endothelial cell proliferation; regulation of hematopoietic progenitor cell differentiation; response to drug; response to hypoxia; sprouting angiogenesis; surfactant homeostasis; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway; vasculogenesis
Reference #:  P35918 (UniProtKB)
Alt. Names/Synonyms: 6130401C07; CD309; Fetal liver kinase 1; Flk; Flk-; FLK-1; Flk1; Kdr; kinase insert domain protein receptor; Kinase NYK; Krd-1; Ly73; orv; OTTMUSP00000023578; Protein-tyrosine kinase receptor flk-1; soluble vascular endothelial growth factor receptor 2; sVEGFR-2; Vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF; VEGF receptor-2; VEGFR; VEGFR-2; VEGFR2; VGFR2
Gene Symbols: Kdr
Molecular weight: 150,462 Da
Basal Isoelectric point: 5.81  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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VEGFR2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein