ITGB1 a type 1 transmembrane protein of the integrin beta chain family. Heterodimerizes with multiple different alpha chains to form receptors for collagen, CSPG4, cytotactin, epiligrin, fibrinogen, fibronectin, fractalkine, IL1B, laminin, osteopontin, PLA2G2A, thrombospondin, VCAM1, and vitronectin. Essential for IL1B signaling. Recognizes the sequence R-G-D in a wide array of ligands. Involved in promoting endothelial cell motility and angiogenesis; osteoblast compaction; and up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. May participate in the adhesion, formation of invadopodia, matrix degradation processes, and promoting cell invasion. ITGA6:ITGB1 is present in oocytes and is involved in sperm-egg fusion. Acts as a coreceptor for human echoviruses 1 and 8, Cytomegalovirus, Epstein-Barr virus, human parvovirus B19, human rotavirus, and mammalian reovirus. In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein, seeming to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin beta chain family. 5 alternatively spliced human isoforms have been reported. Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle). Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 10p11.22
Cellular Component:  cell surface; cleavage furrow; cytoplasm; dendritic spine; external side of plasma membrane; filopodium; focal adhesion; glial cell projection; glutamatergic synapse; integral component of synaptic membrane; integrin alpha1-beta1 complex; integrin alpha10-beta1 complex; integrin alpha11-beta1 complex; integrin alpha2-beta1 complex; integrin alpha3-beta1 complex; integrin alpha7-beta1 complex; integrin alpha8-beta1 complex; integrin complex; intercalated disc; invadopodium membrane; lamellipodium; melanosome; membrane raft; myelin sheath abaxonal region; neuromuscular junction; plasma membrane; protein-containing complex; receptor complex; recycling endosome; ruffle; ruffle membrane; sarcolemma; Schaffer collateral - CA1 synapse
Molecular Function:  actin binding; cell adhesion molecule binding; collagen binding involved in cell-matrix adhesion; coreceptor activity; fibronectin binding; metal ion binding; protease binding; protein binding; protein heterodimerization activity; protein-containing complex binding; virus receptor activity
Biological Process:  axon extension; B cell differentiation; basement membrane organization; calcium-independent cell-matrix adhesion; cardiac muscle cell differentiation; cell adhesion; cell adhesion mediated by integrin; cell fate specification; cell migration; cell migration involved in sprouting angiogenesis; cell projection organization; cell-cell adhesion mediated by integrin; cell-matrix adhesion; cell-substrate adhesion; cellular defense response; cellular response to low-density lipoprotein particle stimulus; cytokine-mediated signaling pathway; dendrite morphogenesis; extracellular matrix organization; formation of radial glial scaffolds; G1/S transition of mitotic cell cycle; germ cell migration; heterotypic cell-cell adhesion; homophilic cell adhesion via plasma membrane adhesion molecules; in utero embryonic development; integrin-mediated signaling pathway; lamellipodium assembly; leukocyte cell-cell adhesion; leukocyte migration; leukocyte tethering or rolling; mesodermal cell differentiation; modulation of chemical synaptic transmission; negative regulation of anoikis; negative regulation of cell differentiation; negative regulation of Rho protein signal transduction; phagocytosis; positive regulation of angiogenesis; positive regulation of apoptotic process; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of GTPase activity; positive regulation of protein kinase B signaling; positive regulation of protein localization to plasma membrane; positive regulation of signaling receptor activity; receptor internalization; regulation of cell cycle; regulation of collagen catabolic process; regulation of immune response; sarcomere organization; viral entry into host cell; visual learning
Reference #:  P05556 (UniProtKB)
Alt. Names/Synonyms: CD29; fibronectin receptor beta subunit; Fibronectin receptor subunit beta; FNRB; Glycoprotein IIa; GPIIA; integrin beta 1; Integrin beta-1; Integrin beta1; integrin subunit beta 1; integrin VLA-4 beta subunit; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITB1; ITGB1; MDF2; MSK12; very late activation protein, beta polypeptide; VLA-4 subunit beta; VLA-BETA; VLAB
Gene Symbols: ITGB1
Molecular weight: 88,415 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein