GPC1 Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Belongs to the glypican family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix; Membrane protein, GPI anchor; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 2q37.3
Cellular Component:  cell surface; cytosol; endosome; extracellular matrix; extracellular space; Golgi lumen; lysosomal lumen; membrane raft; nucleoplasm; plasma membrane; synapse
Molecular Function:  copper ion binding; fibroblast growth factor binding; laminin binding; protein binding
Biological Process:  cell migration; heparan sulfate proteoglycan catabolic process; myelin assembly; negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of skeletal muscle cell differentiation; regulation of protein localization to membrane; Schwann cell differentiation
Reference #:  P35052 (UniProtKB)
Alt. Names/Synonyms: epididymis secretory sperm binding protein; FLJ38078; glypican; glypican 1; glypican proteoglycan 1; Glypican-1; GPC1; Secreted glypican-1
Gene Symbols: GPC1
Molecular weight: 61,680 Da
Basal Isoelectric point: 7.07  Predict pI for various phosphorylation states
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GPC1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene