PKACA catalytic subunit of cAMP-dependent protein kinase alpha, an AGC kinase. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; PKA family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 8|8 C2
Cellular Component:  acrosomal vesicle; cAMP-dependent protein kinase complex; cell projection; centrosome; ciliary base; cilium; cytoplasm; cytoplasmic vesicle; cytosol; dendritic spine; Golgi apparatus; intercellular bridge; membrane; mitochondrion; motile cilium; neuromuscular junction; neuron projection; nuclear speck; nucleotide-activated protein kinase complex; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane raft; protein-containing complex; sperm flagellum; sperm midpiece
Molecular Function:  ATP binding; cAMP-dependent protein kinase activity; kinase activity; magnesium ion binding; manganese ion binding; nucleotide binding; protein binding; protein domain specific binding; protein kinase A regulatory subunit binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein-containing complex binding; Rab GTPase binding; transferase activity; ubiquitin protein ligase binding
Biological Process:  cellular response to glucose stimulus; cellular response to heat; cellular response to parathyroid hormone stimulus; mesoderm formation; modulation of chemical synaptic transmission; mRNA processing; negative regulation of meiotic cell cycle; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; neural tube closure; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of cell cycle arrest; positive regulation of cell proliferation; positive regulation of protein export from nucleus; protein autophosphorylation; protein kinase A signaling; protein phosphorylation; regulation of bicellular tight junction assembly; regulation of cellular respiration; regulation of osteoblast differentiation; regulation of proteasomal protein catabolic process; regulation of protein processing; regulation of synaptic transmission, glutamatergic; sperm capacitation
Reference #:  P05132 (UniProtKB)
Alt. Names/Synonyms: cAMP-dependent protein kinase; cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit C alpha 2; Cs; KAPCA; PKA; PKA C-alpha; Pkaca; PKCD; Prkaca; protein kinase A; protein kinase, cAMP dependent, catalytic, alpha
Gene Symbols: Prkaca
Molecular weight: 40,571 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  NF-kB Signaling  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene