ACTL7B is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known. [provided by RefSeq, Jul 2008]
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q31.3
Cellular Component:  actin cytoskeleton; cytoplasm
Molecular Function:  structural constituent of cytoskeleton
Biological Process:  cytoskeleton organization
Reference #:  Q9Y614 (UniProtKB)
Alt. Names/Synonyms: ACL7B; actin-like 7-beta; actin-like 7B; Actin-like protein 7B; Actin-like-7-beta; ACTL7B; Tact1
Gene Symbols: ACTL7B
Molecular weight: 45,234 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
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ACTL7B

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene