NAGA Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids. Belongs to the glycosyl hydrolase 27 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.2.1.49; Glycan Metabolism - glycosphingolipid biosynthesis - globo series; Hydrolase
Chromosomal Location of human Ortholog: 22q13.2
Cellular Component:  lysosome
Molecular Function:  alpha-N-acetylgalactosaminidase activity; protein homodimerization activity
Biological Process:  carbohydrate catabolic process; glycolipid catabolic process
Disease: Kanzaki Disease; Schindler Disease, Type I
Reference #:  P17050 (UniProtKB)
Alt. Names/Synonyms: Acetylgalactosaminidase, alpha-N- (alpha-galactosidase B); Alpha-galactosidase B; Alpha-N-acetylgalactosaminidase; D22S674; GALB; N-acetylgalactosaminidase, alpha NAGA; N-acetylgalactosaminidase, alpha-; NAGA; NAGAB
Gene Symbols: NAGA
Molecular weight: 46,565 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
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NAGA

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB