PLA2G4A Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase
Chromosomal Location of mouse Ortholog: 1 G1|1 63.51 cM
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; Golgi apparatus; Golgi membrane; intracellular membrane-bounded organelle; membrane; nuclear envelope; nucleus; perinuclear region of cytoplasm; zymogen granule
Molecular Function:  calcium ion binding; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; calcium-independent phospholipase A2 activity; ceramide 1-phosphate binding; histone acetyltransferase binding; hydrolase activity; lipid binding; lysophospholipase activity; metal ion binding; O-acyltransferase activity; phosphatidyl phospholipase B activity; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; phospholipase A2 activity; phospholipase activity
Biological Process:  arachidonic acid metabolic process; arachidonic acid secretion; cellular response to antibiotic; decidualization; establishment of localization in cell; fatty acid biosynthetic process; fatty acid metabolic process; glycerol metabolic process; glycerophospholipid catabolic process; icosanoid biosynthetic process; leukotriene biosynthetic process; lipid catabolic process; lipid metabolic process; monoacylglycerol biosynthetic process; ovulation from ovarian follicle; phosphatidylcholine acyl-chain remodeling; phosphatidylcholine catabolic process; phosphatidylglycerol catabolic process; phospholipid catabolic process; platelet activating factor biosynthetic process; positive regulation of apoptotic process; positive regulation of cell population proliferation; positive regulation of inflammatory response; positive regulation of macrophage activation; positive regulation of platelet activation; positive regulation of prostaglandin biosynthetic process; positive regulation of prostaglandin secretion; positive regulation of T-helper 1 type immune response; positive regulation of vesicle fusion; prostaglandin biosynthetic process; prostaglandin metabolic process; regulation of cell population proliferation; response to calcium ion; response to organic substance; surfactant homeostasis
Reference #:  P47713 (UniProtKB)
Alt. Names/Synonyms: cPL; Cpla2; cPLA2-alpha; cPLA2alpha; Cytosolic phospholipase A2; Cytosolic phospholipase A2 (CPLA2); cytosolic PLA2; Lysophospholipase; OTTMUSP00000017675; PA24A; Phosphatidylcholine 2-acylhydrolase; Phospholipase A2; Phospholipase A2 group IVA; phospholipase A2, group 4; phospholipase A2, group IVA (cytosolic, calcium-dependent); Pla; Pla2g4; Pla2g4a; Type IV PLA2
Gene Symbols: Pla2g4a
Molecular weight: 85,222 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Phospholipase Signaling  |  Regulation of P38 MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene