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cPLA2
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase |
| Chromosomal Location of Human Ortholog: 1 G1|1 63.51 cM |
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Cellular Component:
cytoplasm; cytoplasmic vesicle; cytosol; endoplasmic reticulum; Golgi apparatus; intracellular membrane-bounded organelle; lipid droplet; nucleus; perinuclear region of cytoplasm; zymogen granule
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Molecular Function:
calcium ion binding; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; histone acetyltransferase binding; hydrolase activity; lysophospholipase activity; metal ion binding; phospholipase A2 activity; phospholipase activity
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Biological Process:
arachidonic acid metabolic process; arachidonic acid secretion; cellular response to antibiotic; decidualization; glycerophospholipid catabolic process; icosanoid biosynthetic process; lipid catabolic process; lipid metabolic process; ovulation from ovarian follicle; phospholipid catabolic process; positive regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of inflammatory response; positive regulation of prostaglandin biosynthetic process; positive regulation of vesicle fusion; regulation of cell proliferation; response to calcium ion; response to organic substance; surfactant homeostasis
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Reference #:
P47713
(UniProtKB)
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Alt. Names/Synonyms: Cpla2; cPLA2-alpha; cPLA2alpha; Cytosolic phospholipase A2; Cytosolic phospholipase A2 (CPLA2); cytosolic PLA2; Lysophospholipase; OTTMUSP00000017675; PA24A; Phosphatidylcholine 2-acylhydrolase; Phospholipase A2; Phospholipase A2 group IVA; phospholipase A2, group 4; phospholipase A2, group IVA (cytosolic, calcium-dependent); Pla2g4; Pla2g4a; Type IV PLA2
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Gene Symbols: Pla2g4a
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Molecular weight:
85,222 Da
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Basal Isoelectric point:
5.28
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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Phospholipase Signaling
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Regulation of P38 MAPKs
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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