cPLA2 Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase
Chromosomal Location of mouse Ortholog: 1 G1|1 63.51 cM
Cellular Component:  cytoplasm; cytoplasmic vesicle; cytosol; endoplasmic reticulum; Golgi apparatus; intracellular membrane-bounded organelle; lipid droplet; nucleus; perinuclear region of cytoplasm; zymogen granule
Molecular Function:  calcium ion binding; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; histone acetyltransferase binding; hydrolase activity; lysophospholipase activity; metal ion binding; phospholipase A2 activity; phospholipase activity
Biological Process:  arachidonic acid metabolic process; arachidonic acid secretion; cellular response to antibiotic; decidualization; glycerophospholipid catabolic process; icosanoid biosynthetic process; lipid catabolic process; lipid metabolic process; ovulation from ovarian follicle; phospholipid catabolic process; positive regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of inflammatory response; positive regulation of prostaglandin biosynthetic process; positive regulation of vesicle fusion; regulation of cell proliferation; response to calcium ion; response to organic substance; surfactant homeostasis
Reference #:  P47713 (UniProtKB)
Alt. Names/Synonyms: cPL; Cpla2; cPLA2-alpha; cPLA2alpha; Cytosolic phospholipase A2; Cytosolic phospholipase A2 (CPLA2); cytosolic PLA2; Lysophospholipase; OTTMUSP00000017675; PA24A; Phosphatidylcholine 2-acylhydrolase; Phospholipase A2; Phospholipase A2 group IVA; phospholipase A2, group 4; phospholipase A2, group IVA (cytosolic, calcium-dependent); Pla; Pla2g4; Pla2g4a; Type IV PLA2
Gene Symbols: Pla2g4a
Molecular weight: 85,222 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Phospholipase Signaling  |  Regulation of P38 MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene