CCBL1 Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.6.1.64; EC 2.6.1.7; EC 4.4.1.13; Lyase; Transferase
Chromosomal Location of human Ortholog: 9q34.11
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  cysteine-S-conjugate beta-lyase activity; glutamine-phenylpyruvate transaminase activity; kynurenine-oxoglutarate transaminase activity; protein binding; protein homodimerization activity; pyridoxal phosphate binding; transaminase activity
Biological Process:  cellular amino acid biosynthetic process; cellular modified amino acid metabolic process; kynurenine metabolic process; L-kynurenine catabolic process; L-phenylalanine catabolic process; tryptophan catabolic process
Reference #:  Q16773 (UniProtKB)
Alt. Names/Synonyms: beta-lysase, kidney; CCBL1; cysteine conjugate beta lyase 1; cysteine conjugate-beta lyase; cysteine conjugate-beta lyase, cytoplasmic; Cysteine-S-conjugate beta-lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase); FLJ95217; Glutamine transaminase K; Glutamine--phenylpyruvate transaminase; glutamine-phenylpyruvate aminotransferase; GTK; KAT1; KATI; KYAT1; kyneurenine aminotransferase; kynurenine aminotransferase 1; Kynurenine aminotransferase I; Kynurenine--oxoglutarate transaminase 1; Kynurenine--oxoglutarate transaminase I; MGC29624
Gene Symbols: KYAT1
Molecular weight: 47,875 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Select Structure to View Below

CCBL1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene