PPP1R1A Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. Belongs to the protein phosphatase inhibitor 1 family. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Protein phosphatase, regulatory subunit
Chromosomal Location of rat Ortholog: 7q36
Cellular Component:  cytoplasm; extracellular space
Molecular Function:  protein phosphatase inhibitor activity
Biological Process:  glycogen metabolic process; intracellular signal transduction; negative regulation of catalytic activity; signal transduction
Reference #:  P19103 (UniProtKB)
Alt. Names/Synonyms: I-1; IPP-1; Ipp1; PP1 inhibitor 1; Ppp1r1a; PPR1A; Protein phosphatase 1 regulatory subunit 1A; protein phosphatase 1, regulatory (inhibitor) subunit 1A; Protein phosphatase inhibitor 1
Gene Symbols: Ppp1r1a
Molecular weight: 18,738 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene