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PPP1R1A
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. Belongs to the protein phosphatase inhibitor 1 family. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor; Protein phosphatase, regulatory subunit |
| Chromosomal Location of rat Ortholog: 7q36 |
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Cellular Component:
cytoplasm; extracellular space
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Molecular Function:
protein phosphatase inhibitor activity
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Biological Process:
glycogen metabolic process; intracellular signal transduction; negative regulation of catalytic activity; signal transduction
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Reference #:
P19103
(UniProtKB)
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Alt. Names/Synonyms: I-1; IPP-1; Ipp1; PP1 inhibitor 1; Ppp1r1a; PPR1A; Protein phosphatase 1 regulatory subunit 1A; protein phosphatase 1, regulatory (inhibitor) subunit 1A; Protein phosphatase inhibitor 1
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Gene Symbols: Ppp1r1a
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Molecular weight:
18,738 Da
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Basal Isoelectric point:
5.28
Predict pI for various phosphorylation states
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