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KLF4
Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. Belongs to the krueppel C2H2-type zinc-finger protein family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 9q31.2 |
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Cellular Component:
chromatin; cytosol; euchromatin; microtubule cytoskeleton; nucleoplasm; transcription regulator complex
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Molecular Function:
beta-catenin binding; chromatin DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; promoter-specific chromatin binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; zinc ion binding
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Biological Process:
canonical Wnt signaling pathway; cellular response to growth factor stimulus; cellular response to laminar fluid shear stress; cellular response to leukemia inhibitory factor; defense response to tumor cell; epidermal cell differentiation; epidermis morphogenesis; establishment of skin barrier; fat cell differentiation; gene expression; glandular epithelial cell differentiation; mesodermal cell fate determination; negative regulation of angiogenesis; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell population proliferation; negative regulation of chemokine (C-X-C motif) ligand 2 production; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA-templated transcription; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of heterotypic cell-cell adhesion; negative regulation of inflammatory response; negative regulation of interleukin-8 production; negative regulation of leukocyte adhesion to arterial endothelial cell; negative regulation of NF-kappaB transcription factor activity; negative regulation of response to cytokine stimulus; negative regulation of transcription by RNA polymerase II; positive regulation of core promoter binding; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of hemoglobin biosynthetic process; positive regulation of miRNA transcription; positive regulation of nitric oxide biosynthetic process; positive regulation of protein metabolic process; positive regulation of sprouting angiogenesis; positive regulation of telomerase activity; positive regulation of transcription by RNA polymerase II; post-embryonic camera-type eye development; post-embryonic hemopoiesis; regulation of axon regeneration; regulation of blastocyst development; regulation of cell differentiation; regulation of transcription by RNA polymerase II; response to retinoic acid; somatic stem cell population maintenance; stem cell population maintenance; transcription by RNA polymerase II
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Reference #:
O43474
(UniProtKB)
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Alt. Names/Synonyms: endothelial Kruppel-like zinc finger protein; Epithelial zinc finger protein EZF; EZF; GKLF; gut Kruppel-like factor; Gut-enriched krueppel-like factor; KLF4; Krueppel-like factor 4; Kruppel like factor 4; Kruppel-like factor 4 (gut)
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Gene Symbols: KLF4
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Molecular weight:
54,671 Da
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Basal Isoelectric point:
8.69
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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