IKKA a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B, leading to their dissociation from NF-kappa-B and ultimately to their degradation. Phosphorylated and activated downstream of growth factor receptors, IL1R, and TNFR by NAK, IRAK and NIK, respectively. Preferentially found as a heterodimer with IKK-beta but also as an homodimer. Directly interacts with IKK-gamma/NEMO and TRPC4AP. Heterodimers form the active complex. The tripartite complex can also bind to MAP3K14/NIK, MEKK1, IKAP and IKB-alpha-p65-p50 complex. Inhibitors are under development to treat arthritis, inflammation, and apoptotic aspects of cancer. Aspirin (sodium salicylate) selectively binds IKK and reduces inflammation. Misexpression and inhibitors show involvement in insulin sensitization in obese rodents. Mutations in IKK-gamma are found in several immune deficiencies: hyper IgM syndrome, incontinentia pigmenti [embryonic lethal in males, defects in skin, hair, teeth in females] and hypohidrotic ectodermal dysplasia; recurrent infections and defects in teeth, hair, and sweat glands]. Inhibitors: CHS 828, NBD peptide, BMS-345541. Note: This description may include information from UniProtKB.
Protein type: EC; IKK family; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 19 C3|19 36.71 cM
Cellular Component:  CD40 receptor complex; cytoplasm; cytoplasmic side of plasma membrane; cytosol; IkappaB kinase complex; intracellular membrane-bounded organelle; nucleoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; scaffold protein binding; transferase activity
Biological Process:  cellular response to cadmium ion; cellular response to reactive oxygen species; cellular response to tumor necrosis factor; cellular response to virus; defense response to virus; I-kappaB kinase/NF-kappaB signaling; I-kappaB phosphorylation; lactation; mammary gland alveolus development; mammary gland epithelial cell proliferation; morphogenesis of an epithelial sheet; negative regulation of NF-kappaB transcription factor activity; NIK/NF-kappaB signaling; odontogenesis of dentin-containing tooth; osteoclast differentiation; peptidyl-serine phosphorylation; phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon-alpha secretion; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein phosphorylation; response to cholecystokinin; response to lipopolysaccharide; response to muscle stretch; response to organic substance; Rho protein signal transduction; striated muscle cell differentiation; tumor necrosis factor-mediated signaling pathway
Reference #:  Q60680 (UniProtKB)
Alt. Names/Synonyms: AI256658; Chuk; Chuk1; Conserved helix-loop-helix ubiquitous kinase; Fbx24; Fbxo24; I kappa B kinase 1; I-kappa-B kinase 1; I-kappa-B kinase alpha; IkappaB kinase; IkappaB kinase alpha; IkBKA; IKK alpha; IKK-A; IKK-alpha; IKK1; Ikka; Inhibitor of nuclear factor kappa-B kinase subunit alpha; MGC25325; NFKBIKA; Nuclear factor NF-kappa-B inhibitor kinase alpha
Gene Symbols: Chuk
Molecular weight: 84,729 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene