IkB-alpha a regulatory protein that inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Inhibitor
Chromosomal Location of Human Ortholog: 6q23
Cellular Component:  cytoplasm; cytosol; intracellular; nucleus; plasma membrane
Molecular Function:  enzyme binding; heat shock protein binding; identical protein binding; NF-kappaB binding; nuclear localization sequence binding; ubiquitin protein ligase binding
Biological Process:  cellular response to cytokine stimulus; cellular response to organic cyclic compound; cellular response to tumor necrosis factor; cytoplasmic sequestering of NF-kappaB; cytoplasmic sequestering of transcription factor; I-kappaB kinase/NF-kappaB signaling; lipopolysaccharide-mediated signaling pathway; negative regulation of lipid storage; negative regulation of macrophage derived foam cell differentiation; negative regulation of myeloid cell differentiation; negative regulation of NF-kappaB transcription factor activity; negative regulation of Notch signaling pathway; nucleotide-binding oligomerization domain containing 1 signaling pathway; nucleotide-binding oligomerization domain containing 2 signaling pathway; positive regulation of cellular protein metabolic process; positive regulation of cholesterol efflux; positive regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein import into nucleus, translocation; regulation of cell proliferation; regulation of gene expression; response to exogenous dsRNA; response to lipopolysaccharide; response to muramyl dipeptide; response to muscle stretch; toll-like receptor 4 signaling pathway; tumor necrosis factor-mediated signaling pathway
Reference #:  Q63746 (UniProtKB)
Alt. Names/Synonyms: I-kappa-B-alpha; IkappaBalpha; IkB-alpha; Ikba; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha; NF-kappa-B inhibitor alpha; Nfkbia; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; RL/IF-1
Gene Symbols: Nfkbia
Molecular weight: 35,017 Da
Basal Isoelectric point: 4.65  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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IkB-alpha

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene