MECP2
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). Present in all adult somatic tissues tested. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Transcription, coactivator/corepressor |
Chromosomal Location of rat Ortholog: Xq37 |
Cellular Component:
centrosome; chromatin; cytoplasm; cytosol; glutamatergic synapse; heterochromatin; nucleoplasm; nucleus; postsynapse; protein-containing complex
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Molecular Function:
chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription factor activity; double-stranded methylated DNA binding; enzyme binding; four-way junction DNA binding; histone deacetylase binding; methyl-CpG binding; molecular adaptor activity; molecular condensate scaffold activity; mRNA binding; nucleic acid binding; promoter-specific chromatin binding; protein binding; protein domain specific binding; siRNA binding; transcription corepressor activity; unmethylated CpG binding
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Biological Process:
adult locomotory behavior; associative learning; behavioral fear response; biogenic amine metabolic process; brain development; cardiolipin metabolic process; catecholamine secretion; cell population proliferation; cellular response to isoquinoline alkaloid; cellular response to potassium ion; cerebellum development; cerebral cortex development; chemical synaptic transmission; dendrite development; epigenetic regulation of gene expression; excitatory postsynaptic potential; gene expression; glial cell proliferation; glucocorticoid metabolic process; glutamine metabolic process; heart development; heterochromatin formation; hippocampus development; histone acetylation; histone methylation; inositol metabolic process; learning; long-term memory; long-term synaptic potentiation; lung alveolus development; memory; mitotic spindle organization; multicellular organismal response to stress; negative regulation of angiogenesis; negative regulation of astrocyte differentiation; negative regulation of blood vessel endothelial cell migration; negative regulation of dendrite extension; negative regulation of dendritic spine development; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of locomotion involved in locomotory behavior; negative regulation of neuron apoptotic process; negative regulation of primary miRNA processing; negative regulation of protein binding; negative regulation of respiratory gaseous exchange; negative regulation of smooth muscle cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; nervous system process involved in regulation of systemic arterial blood pressure; neuromuscular process; neuromuscular process controlling posture; neuron differentiation; neuron maturation; neuron projection development; Notch signaling pathway; olfactory bulb development; oligodendrocyte development; oligodendrocyte differentiation; phosphatidylcholine metabolic process; positive regulation of anterograde dense core granule transport; positive regulation of branching morphogenesis of a nerve; positive regulation of cell population proliferation; positive regulation of dendrite extension; positive regulation of dendritic spine development; positive regulation of DNA methylation; positive regulation of DNA-templated transcription; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of glial cell proliferation; positive regulation of histone H3-K9 trimethylation; positive regulation of microtubule nucleation; positive regulation of retrograde dense core granule transport; positive regulation of synaptic plasticity; positive regulation of transcription by RNA polymerase II; post-embryonic development; principal sensory nucleus of trigeminal nerve development; proprioception; protein localization; regulation of action potential firing threshold; regulation of DNA methylation; regulation of gene expression; regulation of gene expression by genomic imprinting; regulation of histone H3-K9 methylation; regulation of respiratory gaseous exchange by nervous system process; regulation of synapse organization; regulation of synaptic plasticity; regulation of transcription by RNA polymerase II; respiratory gaseous exchange by respiratory system; response to cocaine; response to estradiol; response to hypoxia; response to ionizing radiation; response to lead ion; response to organic cyclic compound; response to other organism; sensory perception of pain; social behavior; spinal cord development; startle response; striatum development; synapse assembly; thalamus development; trans-synaptic signaling by BDNF; triglyceride metabolic process; ventricular system development; visual learning
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Reference #:
Q00566
(UniProtKB)
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Alt. Names/Synonyms: MeCp-2 protein; MeCp2; methyl CpG binding protein 2; Methyl-CpG-binding protein 2
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Gene Symbols: Mecp2
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Molecular weight:
53,047 Da
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Basal Isoelectric point:
10.01
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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