PLB Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Belongs to the phospholamban family. Heart muscle (at protein level). Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Membrane protein, integral
Chromosomal Location of Human Ortholog: 10|10 B3
Cellular Component:  endoplasmic reticulum; integral component of membrane; membrane; mitochondrion; protein-containing complex; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; vesicle
Molecular Function:  ATPase inhibitor activity; calcium channel regulator activity; protein binding
Biological Process:  adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; calcium ion transport; cardiac muscle tissue development; cellular calcium ion homeostasis; negative regulation of heart contraction; Notch signaling pathway; protein homooligomerization; regulation of calcium ion import; regulation of cardiac muscle cell contraction; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of heart contraction; regulation of relaxation of muscle; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; regulation of ryanodine-sensitive calcium-release channel activity; regulation of the force of heart contraction; regulation of the force of heart contraction by cardiac conduction; response to testosterone; response to zinc ion
Reference #:  P61014 (UniProtKB)
Alt. Names/Synonyms: Cardiac phospholamban; phospholamban; PLB; Pln; PPLA
Gene Symbols: Pln
Molecular weight: 6,095 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene