ITGB6
Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation. (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1. (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1. Belongs to the integrin beta chain family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis |
Chromosomal Location of human Ortholog: 2q24.2 |
Cellular Component:
cell junction; cell surface; centrosome; external side of plasma membrane; focal adhesion; integrin alphav-beta6 complex; integrin complex; nucleoplasm; plasma membrane; receptor complex
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Molecular Function:
integrin binding; protein binding; virus receptor activity
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Biological Process:
bone development; bronchiole development; cell adhesion; cell adhesion mediated by integrin; cell migration; cell morphogenesis; cell-matrix adhesion; cellular response to ionizing radiation; enamel mineralization; hard palate development; immune response; inflammatory response; integrin-mediated signaling pathway; Langerhans cell differentiation; lung alveolus development; phospholipid homeostasis; regulation of transforming growth factor beta activation; response to virus; skin development; SMAD protein signal transduction; surfactant homeostasis; transforming growth factor beta production; transforming growth factor beta receptor signaling pathway; viral entry into host cell; wound healing
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Disease: Amelogenesis Imperfecta, Type Ih
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Reference #:
P18564
(UniProtKB)
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Alt. Names/Synonyms: AI1H; Integrin beta-6; integrin subunit beta 6; integrin, beta 6; ITB6; ITGB6
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Gene Symbols: ITGB6
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Molecular weight:
85,936 Da
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Basal Isoelectric point:
5.34
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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