PPAP2C Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P. Belongs to the PA-phosphatase related phosphoesterase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - sphingolipid; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Phosphatase, lipid
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  membrane; plasma membrane
Molecular Function:  phosphoprotein phosphatase activity; protein binding
Biological Process:  protein dephosphorylation; sphingolipid biosynthetic process
Reference #:  O43688 (UniProtKB)
Alt. Names/Synonyms: Lipid phosphate phosphohydrolase 2; LPP2; PAP-2c; PAP2-G; PAP2-gamma; PAP2c; Phosphatidate phosphohydrolase type 2c; Phosphatidic acid phosphatase 2c; phosphatidic acid phosphatase type 2C; phosphatidic acid phosphohydrolase type 2c; Phospholipid phosphatase 2; PPAP2C; type-2 phosphatidic acid phosphatase-gamma
Gene Symbols: PLPP2
Molecular weight: 32,574 Da
Basal Isoelectric point: 8.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein