|
CDC25C
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity. Belongs to the MPI phosphatase family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity |
|
Cellular Component:
|
|
Molecular Function:
hydrolase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity
|
|
Biological Process:
cell cycle; cell division; positive regulation of cell cycle G2/M phase transition; protein dephosphorylation
|
|
Reference #:
P30309
(UniProtKB)
|
|
Alt. Names/Synonyms: cdc25; cdc25-1-b; cdc25c; cdc25C2; cell division cycle 25C; M-phase inducer phosphatase 1-B; MPI1B; MPIP3; xcdc25c
|
|
Gene Symbols: cdc25c-b
|
|
Molecular weight:
62,183 Da
|
|
Basal Isoelectric point:
6.03
Predict pI for various phosphorylation states
|
|
CST Pathways:
G2/M DNA Damage Checkpoint
|
GPCR Signaling to MAPKs
|
Growth And Differentiation Control by MAPKs
|
