PLCG2 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Motility/polarity/chemotaxis; Phospholipase
Chromosomal Location of Human Ortholog: 19q12
Cellular Component:  cytosol; membrane; plasma membrane
Molecular Function:  phosphatidylinositol phospholipase C activity; phosphotyrosine residue binding; protein binding
Biological Process:  activation of store-operated calcium channel activity; B cell differentiation; B cell receptor signaling pathway; follicular B cell differentiation; inositol trisphosphate biosynthetic process; intracellular signal transduction; negative regulation of programmed cell death; phosphatidylinositol biosynthetic process; phosphatidylinositol-mediated signaling; phospholipid catabolic process; positive regulation of cytosolic calcium ion concentration; positive regulation of receptor internalization; positive regulation of type I interferon production; regulation of gene expression; release of sequestered calcium ion into cytosol; response to ATP; response to lipopolysaccharide; response to magnesium ion; T cell receptor signaling pathway
Reference #:  P24135 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-gamma-2; phospholipase C, gamma 2; Phospholipase C-gamma-2; Phospholipase C-IV; PLC-gamma-2; PLC-IV; Plcg2
Gene Symbols: Plcg2
Molecular weight: 147,735 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene