|
PLCG2
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. Note: This description may include information from UniProtKB.
|
| Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase |
| Chromosomal Location of rat Ortholog: 19q12 |
|
Cellular Component:
cytoplasm; cytosol; intracellular vesicle; membrane raft; perinuclear region of cytoplasm; plasma membrane; ruffle membrane
|
|
Molecular Function:
phosphatidylinositol phospholipase C activity; phosphorylation-dependent protein binding; phosphotyrosine residue binding; protein binding; protein kinase binding; protein tyrosine kinase binding; scaffold protein binding
|
|
Biological Process:
activation of store-operated calcium channel activity; antifungal innate immune response; B cell differentiation; B cell receptor signaling pathway; calcium-mediated signaling; cell activation; cellular response to calcium ion; cellular response to lectin; cellular response to lipid; follicular B cell differentiation; inositol trisphosphate biosynthetic process; intracellular signal transduction; lipopolysaccharide-mediated signaling pathway; macrophage activation involved in immune response; negative regulation of programmed cell death; phosphatidylinositol biosynthetic process; phosphatidylinositol-mediated signaling; phospholipid catabolic process; positive regulation of calcium-mediated signaling; positive regulation of cell cycle G1/S phase transition; positive regulation of cytosolic calcium ion concentration; positive regulation of dendritic cell cytokine production; positive regulation of DNA-binding transcription factor activity; positive regulation of epithelial cell migration; positive regulation of gene expression; positive regulation of I-kappaB phosphorylation; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-2 production; positive regulation of interleukin-23 production; positive regulation of interleukin-6 production; positive regulation of macrophage cytokine production; positive regulation of MAPK cascade; positive regulation of neuroinflammatory response; positive regulation of NF-kappaB transcription factor activity; positive regulation of NLRP3 inflammasome complex assembly; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phagocytosis, engulfment; positive regulation of reactive oxygen species biosynthetic process; positive regulation of receptor internalization; positive regulation of tumor necrosis factor production; positive regulation of type I interferon production; programmed cell death; regulation of calcineurin-NFAT signaling cascade; regulation of gene expression; regulation of I-kappaB kinase/NF-kappaB signaling; regulation of lipid metabolic process; release of sequestered calcium ion into cytosol; response to ATP; response to axon injury; response to lipopolysaccharide; response to magnesium ion; response to yeast; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; toll-like receptor signaling pathway
|
|
Reference #:
P24135
(UniProtKB)
|
|
Alt. Names/Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-gamma-2; phospholipase C, gamma 2; Phospholipase C-gamma-2; Phospholipase C-IV; PLC-gamma-2; PLC-IV; Plcg2
|
|
Gene Symbols: Plcg2
|
|
Molecular weight:
147,735 Da
|
|
Basal Isoelectric point:
6.4
Predict pI for various phosphorylation states
|
|
CST Pathways:
Actin Dynamics
|
Angiogenesis
|
B Cell Receptor Signaling
|
ErbB/HER Signaling
|
Growth And Differentiation Control by MAPKs
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
