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PLD1
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic. Belongs to the phospholipase D family. Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase |
| Chromosomal Location of Human Ortholog: 3q26.31 |
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Cellular Component:
apical plasma membrane; cholinergic synapse; endocytic vesicle; endoplasmic reticulum membrane; endosome; Golgi apparatus; Golgi membrane; late endosome membrane; perinuclear region of cytoplasm; plasma membrane; specific granule membrane; tertiary granule membrane
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Molecular Function:
N-acylphosphatidylethanolamine-specific phospholipase D activity; phosphatidylinositol binding; phospholipase D activity; protein binding
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Biological Process:
chemotaxis; inositol lipid-mediated signaling; lipid catabolic process; neutrophil degranulation; phosphatidic acid biosynthetic process; Ras protein signal transduction; regulation of microvillus assembly; regulation of synaptic vesicle cycle; small GTPase mediated signal transduction
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Disease: Cardiac Valvular Defect, Developmental
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Reference #:
Q13393
(UniProtKB)
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Alt. Names/Synonyms: Choline phosphatase 1; CVDD; hPLD1; Phosphatidylcholine-hydrolyzing phospholipase D1; Phospholipase D1; phospholipase D1, phophatidylcholine-specific; phospholipase D1, phosphatidylcholine-specific; PLD 1; PLD1
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Gene Symbols: PLD1
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Molecular weight:
124,184 Da
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Basal Isoelectric point:
8.91
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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