XXYLT1 Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose. Known targets include Notch proteins and coagulation factors, such as F9. Belongs to the glycosyltransferase 8 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.4.2.n3; Membrane protein, integral
Chromosomal Location of human Ortholog: 3q29
Cellular Component:  endoplasmic reticulum membrane
Molecular Function:  magnesium ion binding; manganese ion binding; UDP-xylosyltransferase activity; xylosyl alpha-1,3-xylosyltransferase activity
Biological Process:  O-glycan processing
Reference #:  Q8NBI6 (UniProtKB)
Alt. Names/Synonyms: C3orf21; CC021; chromosome 3 open reading frame 21; FLJ35155; hypothetical protein LOC152002; UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase; Uncharacterized protein C3orf21; XXLT1; XXYLT1; Xyloside xylosyltransferase 1
Gene Symbols: XXYLT1
Molecular weight: 43,807 Da
Basal Isoelectric point: 8.35  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene