CDH4 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. Expressed mainly in brain but also found in other tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 2 H4|2 101.86 cM
Cellular Component:  catenin complex; cell surface; cell-cell adherens junction; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane
Molecular Function:  cadherin binding; calcium ion binding; cytoskeletal protein binding; metal ion binding; protein homodimerization activity
Biological Process:  adherens junction organization; axon guidance; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; cell morphogenesis; cell-cell adhesion; cell-cell adhesion mediated by cadherin; cell-cell junction assembly; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; positive regulation of axon extension
Reference #:  P39038 (UniProtKB)
Alt. Names/Synonyms: AW120700; CADH4; cadherin 4; Cadherin-4; Cdh4; OTTMUSP00000017372; R-Ca; R-CAD; R-Cadh; R-cadherin; Rcad; retina cadherin; Retinal cadherin
Gene Symbols: Cdh4
Molecular weight: 100,030 Da
Basal Isoelectric point: 4.65  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene