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PPP1CC
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Belongs to the PPP phosphatase family. PP-1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Nucleolus; Protein phosphatase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 12q24.11 |
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Cellular Component:
chromosome, telomeric region; cleavage furrow; cytoplasm; cytoskeleton; cytosol; dendritic spine; glutamatergic synapse; kinetochore; midbody; mitochondrial outer membrane; mitochondrion; nuclear speck; nucleolus; nucleus; presynapse; protein-containing complex; PTW/PP1 phosphatase complex
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Molecular Function:
lamin binding; metal ion binding; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase 1 binding; protein serine/threonine phosphatase activity; protein-containing complex binding
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Biological Process:
blastocyst development; cell cycle; cell division; circadian regulation of gene expression; entrainment of circadian clock by photoperiod; glycogen metabolic process; MAPK cascade; neuron differentiation; positive regulation of glial cell proliferation; protein dephosphorylation; regulation of circadian rhythm; regulation of nucleocytoplasmic transport; spermatogenesis
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Reference #:
P36873
(UniProtKB)
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Alt. Names/Synonyms: PP-1G; PP1C; PP1G; PP1gamma; PPP1CC; PPP1G; protein phosphatase 1 catalytic subunit gamma; protein phosphatase 1, catalytic subunit, gamma isoform; protein phosphatase 1, catalytic subunit, gamma isozyme; Protein phosphatase 1C catalytic subunit; serine/threonine phosphatase 1 gamma; Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
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Gene Symbols: PPP1CC
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Molecular weight:
36,984 Da
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Basal Isoelectric point:
6.12
Predict pI for various phosphorylation states
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CST Pathways:
Growth And Differentiation Control by MAPKs
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Insulin Receptor Signaling
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Parkinson's Disease
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Translation: eIF2
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