ANKRD1 May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 19|19 C2
Cellular Component:  cytoplasm; cytosol; fibrillar center; I band; myofibril; nucleus; protein-containing complex; transcription factor complex
Molecular Function:  DNA binding; histone deacetylase binding; p53 binding; protein binding; R-SMAD binding; RNA polymerase II sequence-specific DNA-binding transcription factor binding; RNA polymerase II transcription factor binding; titin binding; transcription coactivator activity; transcription corepressor activity; transcription factor binding
Biological Process:  cardiac muscle tissue morphogenesis; cellular response to drug; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; negative regulation of DNA biosynthetic process; negative regulation of transcription by RNA polymerase II; positive regulation of apoptotic process; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of neuron projection development; positive regulation of protein secretion; protein kinase C signaling; regulation of transcription by RNA polymerase II; response to muscle stretch; skeletal muscle cell differentiation; skeletal muscle tissue development
Reference #:  Q9CR42 (UniProtKB)
Alt. Names/Synonyms: Alrp; ANKR1; Ankrd1; ankyrin repeat domain 1 (cardiac muscle); Ankyrin repeat domain-containing protein 1; ankyrin-like repeat protein; Cardiac ankyrin repeat protein; cardiac responsive adriamycin protein; Carp; Crap; MARP1
Gene Symbols: Ankrd1
Molecular weight: 36,004 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
Select Structure to View Below

ANKRD1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene