ANKRD1 May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. Defects in ANKRD1 may be a cause of total anomalous pulmonary venous return (TAPVR). TAPVR is a rare congenital heart disease (CHD) in which the pulmonary veins fail to connect to the left atrium during cardiac development, draining instead into either the right atrium or one of its venous tributaries. This disease accounts for 1.5% of all CHDs and has a prevalence of approximately 1 out of 15'000 live births. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 10q23.31
Cellular Component:  cytoplasm; cytosol; fibrillar center; I band; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  DNA binding; histone deacetylase binding; p53 binding; protein binding; titin binding; transcription corepressor activity
Biological Process:  cardiac muscle morphogensis; myoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; regulation of lipid metabolic process; sarcomere organization
Reference #:  Q15327 (UniProtKB)
Alt. Names/Synonyms: ALRP; ANKR1; ANKRD1; ankyrin repeat domain 1 (cardiac muscle); Ankyrin repeat domain-containing protein 1; bA320F15.2; C-193; C193; Cardiac ankyrin repeat protein; CARP; CVARP; cytokine inducible nuclear protein; Cytokine-inducible nuclear protein; HA1A2; liver ankyrin repeat domain 1; MCARP
Gene Symbols: ANKRD1
Molecular weight: 36,252 Da
Basal Isoelectric point: 7.12  Predict pI for various phosphorylation states
Select Structure to View Below

ANKRD1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene