ANKRD1 May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 10q23.31
Cellular Component:  cytoplasm; cytosol; fibrillar center; I band; nucleoplasm; nucleus
Molecular Function:  DNA binding; histone deacetylase binding; p53 binding; protein binding; R-SMAD binding; RNA polymerase II transcription factor binding; titin binding; transcription coactivator activity; transcription corepressor activity
Biological Process:  cardiac muscle tissue morphogenesis; cellular response to hypoxia; cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to organic cyclic compound; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; negative regulation of DNA biosynthetic process; negative regulation of transcription by RNA polymerase II; positive regulation of apoptotic process; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of neuron projection development; positive regulation of nucleic acid-templated transcription; positive regulation of protein secretion; regulation of lipid metabolic process; response to muscle stretch; sarcomere organization
Reference #:  Q15327 (UniProtKB)
Alt. Names/Synonyms: ALRP; ANKR1; ANKRD1; ankyrin repeat domain 1; ankyrin repeat domain 1 (cardiac muscle); Ankyrin repeat domain-containing protein 1; bA320F15.2; C-193; C193; Cardiac ankyrin repeat protein; CARP; CVARP; cytokine inducible nuclear protein; Cytokine-inducible gene C-193 protein; Cytokine-inducible nuclear protein; epididymis secretory sperm binding protein; HA1A2; liver ankyrin repeat domain 1; MCARP
Gene Symbols: ANKRD1
Molecular weight: 36,252 Da
Basal Isoelectric point: 7.12  Predict pI for various phosphorylation states
Select Structure to View Below

ANKRD1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene