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Jun
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells.
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| Protein type: Oncoprotein; Transcription factor |
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Cellular Component:
nucleus
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Molecular Function:
transcription cis-regulatory region binding
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Biological Process:
positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II
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Reference #:
O77627
(UniProtKB)
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Alt. Names/Synonyms: JUN; Jun proto-oncogene, AP-1 transcription factor subunit; Transcription factor AP-1
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Gene Symbols: JUN
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Molecular weight:
36,084 Da
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Basal Isoelectric point:
8.9
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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B Cell Receptor Signaling
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ErbB/HER Signaling
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SAPK/JNK Signaling Cascades
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T Cell Receptor Signaling
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