HSP105 Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.
Protein type: Chaperone; Heat shock protein
Cellular Component:  microtubule; nucleoplasm; protein-containing complex
Molecular Function:  adenyl-nucleotide exchange factor activity; alpha-tubulin binding; ATP binding
Biological Process:  chaperone cofactor-dependent protein refolding; regulation of catalytic activity
Reference #:  Q0IIM3 (UniProtKB)
Alt. Names/Synonyms: Heat shock protein 105 kDa; heat shock protein family H (Hsp110) member 1; HSP105; HSPH1
Gene Symbols: HSPH1
Molecular weight: 96,726 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein