GJA1
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles. Belongs to the connexin family. Alpha-type (group II) subfamily. Expressed in the heart and fetal cochlea. Note: This description may include information from UniProtKB.
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Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis |
Cellular Component:
apical plasma membrane; cell junction; connexin complex; cytoplasm; early endosome; endoplasmic reticulum; fascia adherens; gap junction; intercalated disc; late endosome; lysosome; mitochondrion; multivesicular body; nucleoplasm; plasma membrane; tight junction
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Molecular Function:
beta-catenin binding; gap junction channel activity; gap junction channel activity involved in cell communication by electrical coupling; gap junction hemi-channel activity; monoatomic ion transmembrane transporter activity; PDZ domain binding; SH3 domain binding; tubulin binding
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Biological Process:
adult heart development; ATP transport; blood vessel morphogenesis; bone development; bone remodeling; cell communication; cell-cell signaling; embryonic heart tube development; epithelial cell maturation; establishment of mitotic spindle orientation; heart development; heart looping; in utero embryonic development; microtubule-based transport; monoatomic ion transmembrane transport; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of gonadotropin secretion; negative regulation of trophoblast cell migration; neuron migration; neuron projection morphogenesis; positive regulation of gene expression; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of mesodermal cell differentiation; positive regulation of morphogenesis of an epithelium; positive regulation of protein catabolic process; positive regulation of stem cell proliferation; positive regulation of striated muscle tissue development; positive regulation of vascular associated smooth muscle cell proliferation; protein complex oligomerization; protein localization; regulation of apoptotic process; regulation of heart contraction; response to pH; signal transduction; skeletal muscle tissue regeneration; spermatogenesis
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Reference #:
P18246
(UniProtKB)
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Alt. Names/Synonyms: Gap junction alpha-1 protein; GJA1
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Gene Symbols: GJA1
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Molecular weight:
43,188 Da
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Basal Isoelectric point:
8.88
Predict pI for various phosphorylation states
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