4E-BP1 Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Belongs to the eIF4E-binding protein family. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Cellular Component:  cytosol
Molecular Function:  eukaryotic initiation factor 4E binding; translation repressor activity
Biological Process:  cellular response to dexamethasone stimulus; G1/S transition of mitotic cell cycle; insulin receptor signaling pathway; IRES-dependent translational initiation of linear mRNA; negative regulation of translational initiation; positive regulation of mitotic cell cycle; TOR signaling
Reference #:  Q0P5A7 (UniProtKB)
Alt. Names/Synonyms: 4E-BP1; EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1
Gene Symbols: EIF4EBP1
Molecular weight: 12,588 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Angiogenesis  |  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein