NCCT Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption. Receptor for the proinflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1. Belongs to the SLC12A transporter family. Predominantly expressed in kidney (PubMed:8812482). Not detected in normal aorta, but abundantly expressed in fatty streaks and advanced atherosclerotic lesions (at protein level) (PubMed:26099046). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 8 C5|8 46.46 cM
Cellular Component:  apical plasma membrane; cytosol; extracellular exosome; integral component of membrane; membrane; plasma membrane; vesicle
Molecular Function:  cation:chloride symporter activity; enzyme binding; potassium:chloride symporter activity; protein binding; sodium ion transmembrane transporter activity; sodium:chloride symporter activity; sodium:potassium:chloride symporter activity; symporter activity
Biological Process:  cell volume homeostasis; chloride ion homeostasis; chloride transmembrane transport; chloride transport; ion transport; potassium ion homeostasis; potassium ion import across plasma membrane; sodium ion homeostasis; sodium ion transmembrane transport; sodium ion transport; transmembrane transport
Reference #:  P59158 (UniProtKB)
Alt. Names/Synonyms: AI035291; Na-Cl symporter; NCC; NCCT; S12A3; Slc12a3; Solute carrier family 12 member 3; solute carrier family 12, member 3; Thiazide-sensitive sodium-chloride cotransporter; Tsc
Gene Symbols: Slc12a3
Molecular weight: 110,694 Da
Basal Isoelectric point: 7.5  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene