ADRB1 Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 19 D2|19 51.96 cM
Cellular Component:  cytoplasm; early endosome; endosome; integral component of membrane; integral component of plasma membrane; intracellular membrane-bounded organelle; membrane; nucleus; plasma membrane; Schaffer collateral - CA1 synapse
Molecular Function:  adrenergic receptor activity; alpha-2A adrenergic receptor binding; beta1-adrenergic receptor activity; dopamine binding; drug binding; epinephrine binding; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential; G protein-coupled receptor activity; norepinephrine binding; PDZ domain binding; protein binding; protein heterodimerization activity; Ras guanyl-nucleotide exchange factor activity
Biological Process:  adenylate cyclase-activating adrenergic receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; apoptotic process; brown fat cell differentiation; diet induced thermogenesis; fear response; G protein-coupled receptor signaling pathway; glycogen catabolic process; heat generation; inhibitory postsynaptic potential; lipid homeostasis; memory; negative regulation of multicellular organism growth; negative regulation of smooth muscle contraction; negative regulation of urine volume; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of adenylate cyclase activity; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of apoptotic process; positive regulation of calcium ion import across plasma membrane; positive regulation of cation channel activity; positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of cold-induced thermogenesis; positive regulation of GTPase activity; positive regulation of heart contraction; positive regulation of heart rate; positive regulation of heart rate by epinephrine-norepinephrine; positive regulation of long-term synaptic potentiation; positive regulation of renin secretion into blood stream; positive regulation of saliva secretion; positive regulation of systemic arterial blood pressure; positive regulation of the force of heart contraction by epinephrine-norepinephrine; positive regulation of the force of heart contraction by norepinephrine; protein localization to organelle; regulation of calcium ion transport; regulation of cardiac muscle cell contraction; response to cold; Rho protein signal transduction; sensory perception of pain; signal transduction; wound healing
Reference #:  P34971 (UniProtKB)
Alt. Names/Synonyms: Adrb; Adrb-1; Adrb1; Adrb1r; adrenergic receptor, beta 1; beta 1-AR; Beta-1 adrenergic receptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor; beta-AR; cardiac beta adrenergic receptor
Gene Symbols: Adrb1
Molecular weight: 50,494 Da
Basal Isoelectric point: 9.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene