ADRB1 Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 10q25.3
Cellular Component:  early endosome; plasma membrane; Schaffer collateral - CA1 synapse
Molecular Function:  alpha-2A adrenergic receptor binding; beta-adrenergic receptor activity; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential; PDZ domain binding; protein binding; protein heterodimerization activity; Ras guanyl-nucleotide exchange factor activity
Biological Process:  activation of adenylate cyclase activity; adenylate cyclase-activating adrenergic receptor signaling pathway; brown fat cell differentiation; diet induced thermogenesis; fear response; G protein-coupled receptor signaling pathway; heat generation; negative regulation of multicellular organism growth; positive regulation of cold-induced thermogenesis; positive regulation of GTPase activity; positive regulation of the force of heart contraction by epinephrine-norepinephrine; regulation of postsynaptic membrane potential; response to cold
Disease: Resting Heart Rate, Variation In; Short Sleep, Familial Natural, 2
Reference #:  P08588 (UniProtKB)
Alt. Names/Synonyms: ADRB1; ADRB1R; adrenergic, beta-1-, receptor; adrenoceptor beta 1; B1AR; Beta-1 adrenergic receptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor; BETA1AR; FNSS2; RHR
Gene Symbols: ADRB1
Molecular weight: 51,323 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene