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PPP1CB
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Belongs to the PPP phosphatase family. PP-1 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; EC 3.1.3.53; Motility/polarity/chemotaxis; Nucleolus; Protein phosphatase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 2p23.2 |
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Cellular Component:
chromosome, telomeric region; cytoplasm; cytosol; glycogen granule; nucleolus; nucleoplasm; nucleus; PTW/PP1 phosphatase complex
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Molecular Function:
metal ion binding; myosin phosphatase activity; myosin-light-chain-phosphatase activity; phosphatase activity; protein binding; protein kinase binding; protein serine/threonine phosphatase activity
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Biological Process:
cell cycle; cell division; circadian regulation of gene expression; entrainment of circadian clock by photoperiod; glycogen metabolic process; MAPK cascade; protein dephosphorylation; regulation of cell adhesion; regulation of circadian rhythm; regulation of glycogen biosynthetic process; regulation of glycogen catabolic process
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Disease: Noonan Syndrome-like Disorder With Loose Anagen Hair 2
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Reference #:
P62140
(UniProtKB)
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Alt. Names/Synonyms: epididymis secretory sperm binding protein Li 80p; HEL-S-80p; MGC3672; MP; myosin phosphatase; NSLH2; PP-1B; PP1B; PP1beta; PP1c; PPP1beta; PPP1CB; PPP1CD; protein phosphatase 1 catalytic subunit beta; protein phosphatase 1, catalytic subunit, beta isoform; protein phosphatase 1, catalytic subunit, beta isozyme; protein phosphatase 1, catalytic subunit, delta isoform; protein phosphatase 1-beta; protein phosphatase 1-delta; serine/threonine protein phosphatase PP1-beta catalytic subunit; Serine/threonine-protein phosphatase PP1-beta catalytic subunit
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Gene Symbols: PPP1CB
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Molecular weight:
37,187 Da
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Basal Isoelectric point:
5.84
Predict pI for various phosphorylation states
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CST Pathways:
Growth And Differentiation Control by MAPKs
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Insulin Receptor Signaling
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Parkinson's Disease
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Translation: eIF2
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