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AVPR1A
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 12q14.2 |
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Cellular Component:
endocytic vesicle; endosome; plasma membrane
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Molecular Function:
peptide binding; peptide hormone binding; protein binding; protein kinase C binding; V1A vasopressin receptor binding; vasopressin receptor activity
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Biological Process:
activation of phospholipase C activity; blood circulation; calcium-mediated signaling; cellular response to hormone stimulus; cellular response to water deprivation; G protein-coupled receptor signaling pathway; generation of precursor metabolites and energy; grooming behavior; maternal aggressive behavior; maternal behavior; myotube differentiation; negative regulation of female receptivity; negative regulation of transmission of nerve impulse; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of cellular pH reduction; positive regulation of cytosolic calcium ion concentration; positive regulation of glutamate secretion; positive regulation of heart rate; positive regulation of prostaglandin biosynthetic process; positive regulation of systemic arterial blood pressure; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure by vasopressin; response to corticosterone; social behavior; sperm ejaculation; telencephalon development; transport across blood-brain barrier
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Reference #:
P37288
(UniProtKB)
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Alt. Names/Synonyms: Antidiuretic hormone receptor 1a; arginine vasopressin receptor 1A; AVPR V1a; AVPR1; AVPR1A; SCCL vasopressin subtype 1a receptor; V1-vascular vasopressin receptor AVPR1A; V1a vasopressin receptor; V1aR; Vascular/hepatic-type arginine vasopressin receptor; Vasopressin V1a receptor
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Gene Symbols: AVPR1A
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Molecular weight:
46,800 Da
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Basal Isoelectric point:
9.48
Predict pI for various phosphorylation states
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