AVPR1A Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 12q14.2
Cellular Component:  endosome; plasma membrane
Molecular Function:  peptide hormone binding; protein binding; protein kinase C binding; V1A vasopressin receptor binding
Biological Process:  activation of phospholipase C activity; blood circulation; calcium-mediated signaling; cellular response to water deprivation; G protein-coupled receptor signaling pathway; generation of precursor metabolites and energy; grooming behavior; maternal aggressive behavior; myotube differentiation; negative regulation of female receptivity; negative regulation of transmission of nerve impulse; penile erection; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular pH reduction; positive regulation of cytosolic calcium ion concentration; positive regulation of glutamate secretion; positive regulation of heart rate; positive regulation of prostaglandin biosynthetic process; positive regulation of renal sodium excretion; positive regulation of systemic arterial blood pressure; response to corticosterone; social behavior; sperm ejaculation; telencephalon development
Reference #:  P37288 (UniProtKB)
Alt. Names/Synonyms: Antidiuretic hormone receptor 1a; arginine vasopressin receptor 1A; AVPR V1a; AVPR1; AVPR1A; SCCL vasopressin subtype 1a receptor; V1-vascular vasopressin receptor AVPR1A; V1a vasopressin receptor; V1aR; Vascular/hepatic-type arginine vasopressin receptor; Vasopressin V1a receptor
Gene Symbols: AVPR1A
Molecular weight: 46,800 Da
Basal Isoelectric point: 9.48  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene