Ig-alpha an integral membrane protein that associates with surface immunoglobulin B lymphocyte antigen receptor multimeric complex. Surface Ig non-covalently associates with 2 other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component:  B cell receptor complex; external side of plasma membrane; integral component of membrane; membrane raft; multivesicular body; plasma membrane
Molecular Function:  protein binding; protein homodimerization activity; transmembrane signaling receptor activity
Biological Process:  adaptive immune response; B cell activation; B cell differentiation; B cell proliferation; B cell receptor signaling pathway; protein homotetramerization
Disease: Agammaglobulinemia 3, Autosomal Recessive
Reference #:  P11912 (UniProtKB)
Alt. Names/Synonyms: B-cell antigen receptor complex-associated protein alpha chain; CD79A; CD79A antigen; CD79a antigen (immunoglobulin-associated alpha); CD79a molecule, immunoglobulin-associated alpha; Ig-alpha; IGA; MB-1; MB-1 membrane glycoprotein; MB1; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein
Gene Symbols: CD79A
Molecular weight: 25,038 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein