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Ig-alpha
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells. B-cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Immunoglobulin superfamily; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 19q13.2 |
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Cellular Component:
B cell receptor complex; external side of plasma membrane; membrane raft; multivesicular body; plasma membrane
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Molecular Function:
identical protein binding; protein binding; transmembrane signaling receptor activity
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Biological Process:
adaptive immune response; B cell activation; B cell differentiation; B cell proliferation; B cell receptor signaling pathway
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Disease: Agammaglobulinemia 3, Autosomal Recessive
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Reference #:
P11912
(UniProtKB)
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Alt. Names/Synonyms: B-cell antigen receptor complex-associated protein alpha chain; CD79A; CD79A antigen; CD79a antigen (immunoglobulin-associated alpha); CD79a molecule; CD79a molecule, immunoglobulin-associated alpha; Ig-alpha; IGA; MB-1; MB-1 membrane glycoprotein; MB1; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein
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Gene Symbols: CD79A
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Molecular weight:
25,038 Da
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Basal Isoelectric point:
4.87
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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