TPMT Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor. TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. Note: This description may include information from UniProtKB.
Protein type: EC 2.1.1.67; Methyltransferase; Xenobiotic Metabolism - drug metabolism - other enzymes
Chromosomal Location of Human Ortholog: 6p22.3
Cellular Component:  cytosol
Molecular Function:  S-adenosyl-L-methionine binding; thiopurine S-methyltransferase activity
Biological Process:  drug metabolic process; methylation; nucleobase-containing compound metabolic process
Disease: Thiopurine S-methyltransferase Deficiency
Reference #:  P51580 (UniProtKB)
Alt. Names/Synonyms: S-adenosyl-L-methionine:thiopurine S-methyltransferase; Thiopurine methyltransferase; Thiopurine S-methyltransferase; TPMT; TPMTD
Gene Symbols: TPMT
Molecular weight: 28,180 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
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TPMT

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene