PPP2CA
PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. Belongs to the PPP phosphatase family. PP-1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor) |
Chromosomal Location of mouse Ortholog: 11|11 B1.3 |
Cellular Component:
chromosome; chromosome, centromeric region; cytoplasm; cytoskeleton; cytosol; membrane raft; nucleus; plasma membrane; protein phosphatase type 2A complex; synapse; terminal bouton
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Molecular Function:
beta-2 adrenergic receptor binding; enzyme binding; GABA receptor binding; hydrolase activity; identical protein binding; metal ion binding; myosin phosphatase activity; phosphoprotein phosphatase activity; protein antigen binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein kinase B binding; protein kinase binding; protein phosphatase 2A binding; protein phosphatase binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein-containing complex binding; tau protein binding; transmembrane transporter binding
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Biological Process:
meiotic cell cycle; mesoderm development; mitotic cell cycle; negative regulation of epithelial to mesenchymal transition; negative regulation of glycolytic process through fructose-6-phosphate; negative regulation of protein kinase B signaling; peptidyl-threonine dephosphorylation; positive regulation of glycolytic process through fructose-6-phosphate; positive regulation of NLRP3 inflammasome complex assembly; positive regulation of protein serine/threonine kinase activity; protein dephosphorylation; regulation of cell cycle; regulation of G1/S transition of mitotic cell cycle; regulation of protein autophosphorylation; regulation of protein catabolic process; regulation of protein phosphorylation; regulation of signaling receptor activity; T cell homeostasis
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Reference #:
P63330
(UniProtKB)
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Alt. Names/Synonyms: OTTMUSP00000005798; PP2A; PP2A-alpha; PP2AA; Ppp2ca; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2a, catalytic subunit, alpha isoform; R75353; RP23-46N3.2; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
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Gene Symbols: Ppp2ca
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Molecular weight:
35,608 Da
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Basal Isoelectric point:
5.3
Predict pI for various phosphorylation states
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CST Pathways:
ESC Pluripotency and Differentiation
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Growth And Differentiation Control by MAPKs
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Insulin Receptor Signaling
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PI3K/Akt Signaling
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TGF-ß Signaling
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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