PPP2CA PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. Belongs to the PPP phosphatase family. PP-1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 11|11 B1.3
Cellular Component:  chromosome; chromosome, centromeric region; cytoplasm; cytoskeleton; cytosol; membrane raft; nucleus; plasma membrane; protein phosphatase type 2A complex; synapse; terminal bouton
Molecular Function:  beta-2 adrenergic receptor binding; enzyme binding; GABA receptor binding; hydrolase activity; identical protein binding; metal ion binding; myosin phosphatase activity; phosphoprotein phosphatase activity; protein antigen binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein kinase B binding; protein kinase binding; protein phosphatase 2A binding; protein phosphatase binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein-containing complex binding; tau protein binding; transmembrane transporter binding
Biological Process:  meiotic cell cycle; mesoderm development; mitotic cell cycle; negative regulation of epithelial to mesenchymal transition; negative regulation of glycolytic process through fructose-6-phosphate; negative regulation of protein kinase B signaling; peptidyl-threonine dephosphorylation; positive regulation of glycolytic process through fructose-6-phosphate; positive regulation of NLRP3 inflammasome complex assembly; positive regulation of protein serine/threonine kinase activity; protein dephosphorylation; regulation of cell cycle; regulation of G1/S transition of mitotic cell cycle; regulation of protein autophosphorylation; regulation of protein catabolic process; regulation of protein phosphorylation; regulation of signaling receptor activity; T cell homeostasis
Reference #:  P63330 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000005798; PP2A; PP2A-alpha; PP2AA; Ppp2ca; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2a, catalytic subunit, alpha isoform; R75353; RP23-46N3.2; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Gene Symbols: Ppp2ca
Molecular weight: 35,608 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling  |  TGF-ß Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PPP2CA

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein