PPAR-gamma Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels. (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein. Belongs to the nuclear hormone receptor family. NR1 subfamily. Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: 6 E3|6 53.41 cM
Cellular Component:  cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleus; perinuclear region of cytoplasm; protein-containing complex; RNA polymerase II transcription factor complex
Molecular Function:  activating transcription factor binding; alpha-actinin binding; arachidonic acid binding; chromatin binding; DBD domain binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; drug binding; E-box binding; enzyme binding; estrogen receptor binding; fatty acid binding; identical protein binding; LBD domain binding; lipid binding; metal ion binding; nuclear receptor activity; nuclear receptor transcription coactivator activity; peptide binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein phosphatase binding; protein self-association; retinoid X receptor binding; RNA polymerase II regulatory region DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II repressing transcription factor binding; signaling receptor activity; steroid hormone receptor activity; transcription factor binding; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding; WW domain binding; zinc ion binding
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; brown fat cell differentiation; cell differentiation; cell fate commitment; cell maturation; cellular response to insulin stimulus; cellular response to lithium ion; cellular response to low-density lipoprotein particle stimulus; cellular response to organic cyclic compound; diet induced thermogenesis; epithelial cell differentiation; fat cell differentiation; fatty acid metabolic process; fatty acid oxidation; glucose homeostasis; hormone-mediated signaling pathway; inflammatory response; lipoprotein transport; long-chain fatty acid transport; low-density lipoprotein particle receptor biosynthetic process; macrophage derived foam cell differentiation; monocyte differentiation; multicellular organism development; negative regulation of acute inflammatory response; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cellular response to insulin stimulus; negative regulation of cholesterol storage; negative regulation of collagen biosynthetic process; negative regulation of cytokine production; negative regulation of gene silencing by miRNA; negative regulation of interferon-gamma-mediated signaling pathway; negative regulation of macrophage derived foam cell differentiation; negative regulation of microglial cell activation; negative regulation of neuroinflammatory response; negative regulation of pancreatic stellate cell proliferation; negative regulation of peptide hormone secretion; negative regulation of receptor biosynthetic process; negative regulation of sequestering of triglyceride; negative regulation of smooth muscle cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of vascular endothelial cell proliferation; negative regulation of vascular smooth muscle cell proliferation; peroxisome proliferator activated receptor signaling pathway; placenta development; positive regulation of apoptotic process; positive regulation of DNA binding; positive regulation of DNA-binding transcription factor activity; positive regulation of fat cell differentiation; positive regulation of fatty acid oxidation; positive regulation of oligodendrocyte differentiation; positive regulation of phagocytosis, engulfment; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of vascular associated smooth muscle cell apoptotic process; pri-miRNA transcription by RNA polymerase II; regulation of blood pressure; regulation of circadian rhythm; regulation of fat cell differentiation; regulation of gene expression; regulation of lipid metabolic process; regulation of transcription by RNA polymerase II; regulation of transcription involved in cell fate commitment; regulation of transcription, DNA-templated; response to dietary excess; response to food; response to light stimulus; response to lipid; response to retinoic acid; rhythmic process; signal transduction; white fat cell differentiation
Reference #:  P37238 (UniProtKB)
Alt. Names/Synonyms: Nr1; Nr1c3; Nuclear receptor subfamily 1 group C member 3; peroxisome proliferator activated receptor gamma; peroxisome proliferator activated receptor gamma 2; peroxisome proliferator activated receptor gamma 4; Peroxisome proliferator-activated receptor gamma; PPA; PPAR; Ppar-; PPAR-gamma; PPAR-gamma2; Pparg; PPARgamma; PPARgamma2
Gene Symbols: Pparg
Molecular weight: 57,598 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  mTOR Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PPAR-gamma

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA