PIK3C2G Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis. Belongs to the PI3/PI4-kinase family. Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 12p12.3
Cellular Component:  cytosol
Molecular Function:  1-phosphatidylinositol-3-kinase activity; ATP binding; phosphatidylinositol binding; phosphatidylinositol phosphate kinase activity
Biological Process:  chemotaxis; phosphatidylinositol biosynthetic process; viral RNA genome replication
Reference #:  O75747 (UniProtKB)
Alt. Names/Synonyms: MGC163149; P3C2G; phosphatidylinositol 3-kinase C2 domain-containing gamma; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide; Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Phosphoinositide 3-kinase-C2-gamma; phosphoinositide-3-kinase, class 2, gamma polypeptide; PI3K-C2-gamma; PI3K-C2GAMMA; PIK3C2G; PTDINS-3-kinase C2 gamma; PtdIns-3-kinase C2 subunit gamma
Gene Symbols: PIK3C2G
Molecular weight: 165,715 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB