HSP27 Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. Belongs to the small heat shock protein (HSP20) family. Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid. Highest levels are found in the heart and in tissues composed of striated and smooth muscle. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Heat shock protein; Motility/polarity/chemotaxis
Chromosomal Location of rat Ortholog: 12q12
Cellular Component:  axon; axon cytoplasm; cardiac myofibril; contractile fiber; cytoplasm; dendrite; I band; M band; nucleus; perikaryon; plasma membrane; postsynaptic density membrane; proteasome complex; spindle; synapse; Z disc
Molecular Function:  identical protein binding; protein binding; protein binding involved in protein folding; protein homodimerization activity; protein kinase binding; protein kinase C binding; protein kinase C inhibitor activity; ubiquitin binding
Biological Process:  aging; anterograde axonal protein transport; cellular response to butyrate; cellular response to hydrogen peroxide; cellular response to interleukin-11; cellular response to vascular endothelial growth factor stimulus; chaperone-mediated protein folding; female pregnancy; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of oxidative stress-induced cell death; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell chemotaxis; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of interleukin-1 beta production; positive regulation of neuron projection development; positive regulation of tumor necrosis factor biosynthetic process; regulation of I-kappaB kinase/NF-kappaB signaling; regulation of protein phosphorylation; response to angiotensin; response to ischemia; response to muscle stretch; response to virus
Reference #:  P42930 (UniProtKB)
Alt. Names/Synonyms: Heat shock 27 kDa protein; heat shock 27 kDa protein 1; heat shock 27kDa protein 1; heat shock protein 1; Heat shock protein beta-1; HSP 27; Hsp25; Hsp27; HspB1
Gene Symbols: Hspb1
Molecular weight: 22,893 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
CST Pathways:  Inhibition of Apoptosis  |  Regulation of P38 MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene