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PEX19
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. Belongs to the peroxin-19 family. Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Chaperone; Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: 1 H3|1 79.54 cM |
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Cellular Component:
brush border membrane; cytoplasm; cytosol; membrane; nucleoplasm; nucleus; peroxisomal membrane; peroxisome; protein-containing complex
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Molecular Function:
ATPase binding; peroxisome membrane class-1 targeting sequence binding; peroxisome membrane targeting sequence binding; protein binding; protein carrier chaperone
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Biological Process:
chaperone-mediated protein folding; establishment of protein localization to peroxisome; negative regulation of lipid binding; peroxisome fission; peroxisome membrane biogenesis; peroxisome organization; protein import into peroxisome membrane; protein stabilization; protein targeting to peroxisome
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Reference #:
Q8VCI5
(UniProtKB)
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Alt. Names/Synonyms: Peroxin-19; Peroxisomal biogenesis factor 19; Peroxisomal farnesylated protein; peroxisome biogenesis factor 19; Pex19; PxF
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Gene Symbols: Pex19
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Molecular weight:
32,733 Da
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Basal Isoelectric point:
4.26
Predict pI for various phosphorylation states
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