PR a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: 9|9 A1
Cellular Component:  axon; axon terminus; cytoplasm; cytosol; dendrite; dendritic spine; endoplasmic reticulum; mitochondrion; neuron projection; nucleus; perikaryon; plasma membrane
Molecular Function:  ATPase binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; enzyme binding; hormone binding; identical protein binding; lipid binding; metal ion binding; nuclear receptor activity; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; signaling receptor binding; steroid binding; steroid hormone receptor activity; zinc ion binding
Biological Process:  epithelial cell maturation; female mating behavior; lung alveolus development; mammary gland development; negative regulation of apoptotic process; negative regulation of granulosa cell apoptotic process; ovulation from ovarian follicle; paracrine signaling; positive regulation of cell proliferation; positive regulation of smooth muscle cell migration; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; progesterone receptor signaling pathway; regulation of epithelial cell proliferation; regulation of transcription, DNA-templated; response to cocaine; steroid hormone mediated signaling pathway; tertiary branching involved in mammary gland duct morphogenesis
Reference #:  Q00175 (UniProtKB)
Alt. Names/Synonyms: 9930019P03Rik; BB114106; ENSMUSG00000074510; Nr3c3; Nuclear receptor subfamily 3 group C member 3; OTTMUSP00000026522; Pgr; PR-A; PR-B; PRGR; Progesterone receptor
Gene Symbols: Pgr
Molecular weight: 98,981 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA