|
GSK3B
a constitutively active proline-directed protein kinase. Involved in energy metabolism, neuronal cell development, and body pattern formation. Acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling, and regulation of transcription factors and microtubules. Regulates protein synthesis by controlling the activity of EIF2B. In Wnt signaling, GSK3B phosphorylates CTNNB1 leading to its degradation. Phosphorylates and inactivates APC, AXIN1, CRMP2, JUN, NFATC, MAPT and MACF1. Is necessary for the establishment of neuronal polarity and axon outgrowth. Regulates the circadian clock via phosphorylation of major clock components. Acts as a regulator of autophagy by activating TIP60, thus promoting the acetylation of key autophagy regulators. Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain. Most of its substrates require priming by phosphorylation of a residue C-terminal to the targeted serine or threonine. Belongs to the protein kinase superfamily, CMGC Ser/Thr kinase family, GSK-3 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: CMGC group; EC 2.7.11.1; EC 2.7.11.26; GSK family; GSK subfamily; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: 16|16 B3 |
|
Cellular Component:
axon; beta-catenin destruction complex; centrosome; cytoplasm; cytosol; dendrite; dendritic shaft; dendritic spine; glutamatergic synapse; growth cone; meiotic spindle; membrane; membrane-bounded organelle; microtubule; neuronal cell body; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; protein-containing complex; ribonucleoprotein complex; Schaffer collateral - CA1 synapse; Wnt signalosome
|
|
Molecular Function:
ATP binding; beta-catenin binding; dynactin binding; dynein complex binding; integrin binding; ionotropic glutamate receptor binding; kinase activity; NF-kappaB binding; nucleotide binding; p53 binding; protease binding; protein binding; protein kinase A catalytic subunit binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase binding; RNA polymerase II-specific DNA-binding transcription factor binding; tau protein binding; tau-protein kinase activity; transferase activity; ubiquitin protein ligase binding
|
|
Biological Process:
animal organ morphogenesis; axon extension; axonogenesis; beta-catenin destruction complex disassembly; bone remodeling; canonical Wnt signaling pathway; carbohydrate metabolic process; cell differentiation; cell growth involved in cardiac muscle cell development; cell migration; cellular response to amyloid-beta; cellular response to glucocorticoid stimulus; cellular response to hepatocyte growth factor stimulus; cellular response to interleukin-3; cellular response to mechanical stimulus; cellular response to retinoic acid; circadian rhythm; cytoskeleton organization; epithelial to mesenchymal transition; ER overload response; establishment of cell polarity; establishment or maintenance of cell polarity; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; fat cell differentiation; glycogen metabolic process; hepatic stellate cell activation; hepatocyte apoptotic process; hippocampus development; insulin receptor signaling pathway; intracellular signal transduction; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; maintenance of cell polarity; meiosis I; multicellular organism development; myoblast fusion; myotube differentiation; negative regulation of apoptotic process; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation; negative regulation of cardiac muscle hypertrophy; negative regulation of dendrite development; negative regulation of dendrite morphogenesis; negative regulation of dopaminergic neuron differentiation; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of gene expression; negative regulation of gene expression via CpG island methylation; negative regulation of insulin receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of mesenchymal stem cell differentiation; negative regulation of neuron maturation; negative regulation of neuron migration; negative regulation of neuron projection development; negative regulation of nitric-oxide synthase activity; negative regulation of protein acetylation; negative regulation of protein binding; negative regulation of protein localization to centrosome; negative regulation of protein localization to nucleus; negative regulation of protein-containing complex assembly; negative regulation of signal transduction; negative regulation of smooth muscle cell apoptotic process; negative regulation of synaptic assembly at neuromuscular junction; negative regulation of TOR signaling; nervous system development; neuron projection development; neuron projection organization; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of axon extension; positive regulation of cardiac muscle cell differentiation; positive regulation of cell differentiation; positive regulation of cell-matrix adhesion; positive regulation of cilium assembly; positive regulation of DNA biosynthetic process; positive regulation of excitatory postsynaptic potential; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of mitochondrial membrane potential; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; positive regulation of mitochondrion organization; positive regulation of neuron apoptotic process; positive regulation of osteoblast proliferation; positive regulation of osteoclast differentiation; positive regulation of osteoclast proliferation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; positive regulation of protein catabolic process; positive regulation of protein export from nucleus; positive regulation of protein localization to centrosome; positive regulation of protein localization to cilium; positive regulation of protein ubiquitination; positive regulation of protein-containing complex assembly; positive regulation of smooth muscle cell proliferation; positive regulation of stem cell differentiation; positive regulation of synaptic assembly at neuromuscular junction; positive regulation of transcription by RNA polymerase II; presynaptic modulation of chemical synaptic transmission; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autophosphorylation; protein export from nucleus; protein kinase B signaling; protein localization to microtubule; protein phosphorylation; re-entry into mitotic cell cycle; regulation of apoptotic process; regulation of axon extension; regulation of axonogenesis; regulation of cell growth; regulation of circadian rhythm; regulation of dendrite morphogenesis; regulation of gene expression by genomic imprinting; regulation of long-term synaptic potentiation; regulation of microtubule anchoring at centrosome; regulation of microtubule cytoskeleton organization; regulation of microtubule-based process; regulation of modification of postsynaptic structure; regulation of neuron projection development; regulation of neuronal synaptic plasticity; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of osteoblast differentiation; regulation of protein export from nucleus; response to zinc ion; rhythmic process; stem cell differentiation; superior temporal gyrus development; transcription by RNA polymerase II; Wnt signaling pathway
|
|
Reference #:
Q9WV60
(UniProtKB)
|
|
Alt. Names/Synonyms: 7330414F15Rik; 8430431H08Rik; C86142; glycogen synthase kinase 3 beta; Glycogen synthase kinase-3 beta; GSK; GSK-; GSK-3; GSK-3 beta; GSK-3be; GSK-3beta; GSK3; Gsk3b; GSK3beta; OTTMUSP00000017445; Serine/threonine-protein kinase GSK3B
|
|
Gene Symbols: Gsk3b
|
|
Molecular weight:
46,710 Da
|
|
Basal Isoelectric point:
8.98
Predict pI for various phosphorylation states
|
|
CST Pathways:
Adherens Junction Dynamics
|
Alzheimer's Disease
|
B Cell Receptor Signaling
|
ErbB/HER Signaling
|
ESC Pluripotency and Differentiation
|
G1/S Checkpoint
|
Growth And Differentiation Control by MAPKs
|
Hedgehog Signaling
|
Inhibition of Apoptosis
|
Insulin Receptor Signaling
|
Microtubule Dynamics
|
mTOR Signaling
|
NF-kB Signaling
|
PI3K/Akt Signaling
|
Translation: eIF2
|
Translation: eIF4E and p70S6K
|
Wnt/ß-Catenin Signaling
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
