GSK3B a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC; EC; GSK family; GSK subfamily; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 16|16 B3
Cellular Component:  axon; beta-catenin destruction complex; cell body; centrosome; cytoplasm; cytosol; dendrite; dendritic shaft; dendritic spine; glutamatergic synapse; growth cone; membrane; membrane raft; membrane-bounded organelle; microtubule; mitochondrion; neuronal cell body; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; protein-containing complex; ribonucleoprotein complex; Schaffer collateral - CA1 synapse; Wnt signalosome
Molecular Function:  ATP binding; beta-catenin binding; dynactin binding; dynein complex binding; integrin binding; ionotropic glutamate receptor binding; kinase activity; NF-kappaB binding; nucleotide binding; p53 binding; protease binding; protein binding; protein kinase A catalytic subunit binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; RNA polymerase II transcription factor binding; tau protein binding; tau-protein kinase activity; transcription factor binding; transferase activity; ubiquitin protein ligase binding
Biological Process:  animal organ morphogenesis; axonogenesis; bone remodeling; canonical Wnt signaling pathway; carbohydrate metabolic process; cell differentiation; cell growth involved in cardiac muscle cell development; cell migration; cellular response to amyloid-beta; cellular response to hepatocyte growth factor stimulus; cellular response to interleukin-3; cellular response to mechanical stimulus; circadian rhythm; cytoskeleton organization; epithelial to mesenchymal transition; ER overload response; establishment of cell polarity; establishment or maintenance of cell polarity; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; fat cell differentiation; glycogen metabolic process; hepatic stellate cell activation; hepatocyte apoptotic process; hippocampus development; hypermethylation of CpG island; insulin receptor signaling pathway; intracellular signal transduction; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; maintenance of cell polarity; multicellular organism development; myoblast fusion; myotube differentiation; negative regulation of apoptotic process; negative regulation of calcineurin-NFAT signaling cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle hypertrophy; negative regulation of dendrite development; negative regulation of dendrite morphogenesis; negative regulation of dopaminergic neuron differentiation; negative regulation of MAP kinase activity; negative regulation of neuron death; negative regulation of neuron maturation; negative regulation of neuron migration; negative regulation of neuron projection development; negative regulation of nitric-oxide synthase activity; negative regulation of protein acetylation; negative regulation of protein binding; negative regulation of protein complex assembly; negative regulation of protein localization to centrosome; negative regulation of protein localization to nucleus; negative regulation of signal transduction; negative regulation of smooth muscle cell apoptotic process; negative regulation of TOR signaling; nervous system development; neuron projection development; neuron projection organization; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of axon extension; positive regulation of cardiac muscle cell differentiation; positive regulation of cell-matrix adhesion; positive regulation of DNA biosynthetic process; positive regulation of excitatory postsynaptic potential; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of mitochondrial membrane potential; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; positive regulation of mitochondrion organization; positive regulation of neuron apoptotic process; positive regulation of neuron death; positive regulation of osteoblast proliferation; positive regulation of osteoclast differentiation; positive regulation of osteoclast proliferation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; positive regulation of protein catabolic process; positive regulation of protein complex assembly; positive regulation of protein export from nucleus; positive regulation of protein localization to centrosome; positive regulation of smooth muscle cell proliferation; positive regulation of stem cell differentiation; positive regulation of transcription by RNA polymerase II; protein autophosphorylation; protein export from nucleus; protein localization to microtubule; protein phosphorylation; re-entry into mitotic cell cycle; regulation of apoptotic process; regulation of axon extension; regulation of axonogenesis; regulation of cell growth; regulation of circadian rhythm; regulation of dendrite morphogenesis; regulation of gene expression by genetic imprinting; regulation of long-term synaptic potentiation; regulation of microtubule cytoskeleton organization; regulation of microtubule-based process; regulation of modification of postsynaptic structure; regulation of neuron projection development; regulation of neuronal synaptic plasticity; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of osteoblast differentiation; regulation of synaptic vesicle exocytosis; response to zinc ion; rhythmic process; superior temporal gyrus development; Wnt signaling pathway
Reference #:  Q9WV60 (UniProtKB)
Alt. Names/Synonyms: 7330414F15Rik; 8430431H08Rik; C86142; glycogen synthase kinase 3 beta; Glycogen synthase kinase-3 beta; GSK-3; GSK-3 beta; GSK-3beta; GSK3; Gsk3b; OTTMUSP00000017445
Gene Symbols: Gsk3b
Molecular weight: 46,710 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Alzheimer's Disease  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  G1/S Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Translation: eIF2  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene