PCCA 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - propanoate; EC; Ligase; Mitochondrial
Chromosomal Location of human Ortholog: 13q32.3
Cellular Component:  catalytic complex; cytosol; mitochondrial matrix; mitochondrion
Molecular Function:  ATP binding; biotin binding; enzyme binding; metal ion binding; propionyl-CoA carboxylase activity; protein binding
Biological Process:  branched-chain amino acid metabolic process; fatty acid metabolic process; short-chain fatty acid catabolic process
Disease: Propionic Acidemia
Reference #:  P05165 (UniProtKB)
Alt. Names/Synonyms: PCCA; pccA complementation group; PCCase alpha subunit; PCCase subunit alpha; propanoyl-CoA:carbon dioxide ligase alpha subunit; Propanoyl-CoA:carbon dioxide ligase subunit alpha; propionyl CoA carboxylase, alpha polypeptide; propionyl Coenzyme A carboxylase, alpha polypeptide; Propionyl-CoA carboxylase alpha chain, mitochondrial; propionyl-CoA carboxylase alpha subunit; propionyl-CoA carboxylase subunit alpha; propionyl-Coenzyme A carboxylase, alpha polypeptide
Gene Symbols: PCCA
Molecular weight: 80,059 Da
Basal Isoelectric point: 7.24  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein