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PCCA
3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - propanoate; EC 6.4.1.3; Ligase; Mitochondrial |
| Chromosomal Location of human Ortholog: 13q32.3 |
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Cellular Component:
catalytic complex; cytosol; mitochondrial matrix; mitochondrion
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Molecular Function:
ATP binding; biotin binding; enzyme binding; metal ion binding; propionyl-CoA carboxylase activity; protein binding
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Biological Process:
branched-chain amino acid metabolic process; fatty acid metabolic process; short-chain fatty acid catabolic process
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Disease: Propionic Acidemia
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Reference #:
P05165
(UniProtKB)
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Alt. Names/Synonyms: PCCA; pccA complementation group; PCCase alpha subunit; PCCase subunit alpha; propanoyl-CoA:carbon dioxide ligase alpha subunit; Propanoyl-CoA:carbon dioxide ligase subunit alpha; propionyl CoA carboxylase, alpha polypeptide; propionyl Coenzyme A carboxylase, alpha polypeptide; Propionyl-CoA carboxylase alpha chain, mitochondrial; propionyl-CoA carboxylase alpha subunit; propionyl-CoA carboxylase subunit alpha; propionyl-Coenzyme A carboxylase, alpha polypeptide
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Gene Symbols: PCCA
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Molecular weight:
80,059 Da
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Basal Isoelectric point:
7.24
Predict pI for various phosphorylation states
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