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SHB
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of rat Ortholog: 5q22 |
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Cellular Component:
cytoplasmic ribonucleoprotein granule; cytosol; nucleoplasm
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Molecular Function:
phosphotyrosine residue binding; signaling receptor complex adaptor activity
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Biological Process:
B cell proliferation; blood vessel development; blood vessel morphogenesis; hematopoietic stem cell proliferation; hemopoiesis; negative regulation of oocyte maturation; negative regulation of protein kinase activity; positive regulation of mitotic cell cycle; positive regulation of T-helper cell differentiation; T cell receptor signaling pathway
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Reference #:
XP_002726568
(RefSeq)
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Alt. Names/Synonyms: RGD1565350; SH2 domain containing adaptor protein B; Shb
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Gene Symbols: Shb
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Molecular weight:
54,531 Da
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Basal Isoelectric point:
9.01
Predict pI for various phosphorylation states
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