PCK1 Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate. Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. Major sites of expression are liver, kidney and adipocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 4.1.1.32; Kinase, other; Lyase; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 20q13.31
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; mitochondrion
Molecular Function:  carboxylic acid binding; GTP binding; magnesium ion binding; manganese ion binding; phosphoenolpyruvate carboxykinase (GTP) activity; protein serine kinase activity (using GTP as donor)
Biological Process:  cellular response to dexamethasone stimulus; cellular response to glucose stimulus; cellular response to insulin stimulus; cellular response to potassium ion starvation; gluconeogenesis; glucose homeostasis; glucose metabolic process; glycerol biosynthetic process from pyruvate; hepatocyte differentiation; oxaloacetate metabolic process; peptidyl-serine phosphorylation; positive regulation of memory T cell differentiation; positive regulation of transcription from RNA polymerase II promoter in response to acidic pH; propionate catabolic process; regulation of lipid biosynthetic process; response to bacterium; response to insulin; response to lipid; response to starvation
Disease: Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic
Reference #:  P35558 (UniProtKB)
Alt. Names/Synonyms: MGC22652; PCK1; PCKDC; PCKGC; PEP carboxykinase; PEPCK-C; PEPCK1; PEPCKC; phosphoenolpyruvate carboxykinase 1; phosphoenolpyruvate carboxykinase 1 (soluble); phosphoenolpyruvate carboxykinase, cytosolic; Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Phosphoenolpyruvate carboxylase; phosphopyruvate carboxylase; Serine-protein kinase PCK1
Gene Symbols: PCK1
Molecular weight: 69,195 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PCK1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene