TRMT1 Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.1.1.216; Methyltransferase
Chromosomal Location of Human Ortholog: 19p13.13
Cellular Component:  mitochondrion; nucleoplasm; nucleus
Molecular Function:  metal ion binding; protein binding; RNA binding; tRNA (guanine-N2-)-methyltransferase activity; tRNA binding
Biological Process:  tRNA modification
Reference #:  Q9NXH9 (UniProtKB)
Alt. Names/Synonyms: FLJ20244; N(2),N(2)-dimethylguanosine tRNA methyltransferase; TRM1; TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae); TRMT1; tRNA (guanine(26)-N(2))-dimethyltransferase; tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA methyltransferase 1; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase
Gene Symbols: TRMT1
Molecular weight: 72,234 Da
Basal Isoelectric point: 7.77  Predict pI for various phosphorylation states
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TRMT1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein