GRK2 a ubiquitous protein kinase of the GRK family. Phosphorylates the beta-2-adrenergic receptor and related G-protein-coupled receptors. Appears to mediate agonist-specific desensitization observed at high agonist concentrations. Expression level is consistently elevated in chronic human heart failure. Mouse models of severe heart failure have been used to demonstrate that inhibition of BARK1 with a peptide inhibitor is sufficient to increase mean survival, reduce dialation and improve cardiac function. Note: This description may include information from UniProtKB.
Protein type: AGC group; BARK subfamily; EC; GRK family; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 1q43
Cellular Component:  apical plasma membrane; axon; basolateral plasma membrane; caveola; cytoplasm; cytosol; dendritic shaft; dendritic spine; membrane; membrane raft; mitochondrion; nucleus; synapse
Molecular Function:  ATP binding; beta-adrenergic receptor kinase activity; delta-type opioid receptor binding; Edg-2 lysophosphatidic acid receptor binding; G protein-coupled receptor binding; G protein-coupled receptor kinase activity; kappa-type opioid receptor binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; scaffold protein binding; ubiquitin protein ligase binding
Biological Process:  aging; cardiac muscle contraction; cellular response to catecholamine stimulus; cellular response to chemokine; cellular response to epidermal growth factor stimulus; cellular response to glucose stimulus; cellular response to organic cyclic compound; cellular response to phorbol 13-acetate 12-myristate; cellular response to rapamycin; desensitization of G protein-coupled receptor signaling pathway; follicle-stimulating hormone signaling pathway; G protein-coupled receptor signaling pathway; heart development; maintenance of protein location in nucleus; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of apoptotic process; negative regulation of blood vessel diameter; negative regulation of cellular response to insulin stimulus; negative regulation of cysteine-type endopeptidase activity; negative regulation of G protein-coupled receptor signaling pathway; negative regulation of glucose import; negative regulation of peptidyl-serine phosphorylation; negative regulation of peptidyl-threonine phosphorylation; negative regulation of striated muscle contraction; negative regulation of the force of heart contraction by chemical signal; oligodendrocyte differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of catecholamine secretion; positive regulation of excitatory postsynaptic potential; positive regulation of fibroblast proliferation; positive regulation of interleukin-6 biosynthetic process; positive regulation of muscle cell apoptotic process; positive regulation of sensory perception of pain; positive regulation of vascular smooth muscle cell proliferation; positive regulation of vasoconstriction; protein phosphorylation; receptor internalization; regulation of the force of heart contraction; response to caloric restriction; response to hydrogen peroxide; response to leptin; response to morphine; response to muscle activity; response to organic cyclic compound; response to oxidative stress; tachykinin receptor signaling pathway; viral entry into host cell; viral genome replication
Reference #:  P26817 (UniProtKB)
Alt. Names/Synonyms: Adrbk1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; ARBK1; BARK1; Beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; Beta-ARK-1; G-protein-coupled receptor kinase 2; GRK-2; Grk2
Gene Symbols: Adrbk1
Molecular weight: 79,785 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene