MTMR3 Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; EC; EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component:  cytoplasm; cytosol; extrinsic component of membrane; membrane
Molecular Function:  metal ion binding; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphatase activity; protein binding; protein phosphatase binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity
Biological Process:  cellular response to glucose starvation; macroautophagy; peptidyl-tyrosine dephosphorylation; phosphatidylinositol 5-phosphate metabolic process; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; protein dephosphorylation; regulation of autophagosome assembly; regulation of phosphatidylinositol dephosphorylation
Reference #:  Q13615 (UniProtKB)
Alt. Names/Synonyms: FLJ32333; FYVE (Fab1 YGLO23 Vsp27 EEA1 domain) dual-specificity protein phosphatase; FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; KIAA0371; MTMR3; myotubularin related protein 3; Myotubularin-related protein 3; ZFYVE10; Zinc finger FYVE domain-containing protein 10; zinc finger, FYVE domain containing 10
Gene Symbols: MTMR3
Molecular weight: 133,619 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein